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MIDNIGHT · #3 (**permalink**) 01-20-2010, 11:01 PM

DOSING

For anti-aging, general health & healing, fat mobilization
And other purposes such as these –
A dose of 2-3 IU’s per day (~10 – 15 IU’s per week) will be sufficient. A dose of 1.5 - 2.0 IU’s is considered to be a full replacement dose for those in their middle age. Given we will get somewhere in the neighborhood of 70-80% absorption and utilization from our subQ injections, our 2-3 IU’s will for all intents and purposes equate to a full replacement measure of HGH.

For gaining lean muscle and substantially improving body composition –
For this purpose a dose of 5-10 IU’s per day (~25-50 IU’s per week) will be necessary. Most people that still have an alive and kicking pituitary will respond very well at a dose of 5 IU’s per day, though advanced bodybuilders and other large strength athletes will find that dose approaching 10 IU’s per day will be in order.
For maximum benefit in this regard, the addition of Testosterone and/or other anabolic should strongly be considered. For advanced use, other supplements like Insulin, and low-dose T3 or T4 would also be considerations.

Regardless of your goal, as a general rule the best way to begin your HGH program is to start with a low dose and ease your body into the higher doses. This will allow you to avoid (or at least minimize) many of the more common (and unpleasant) sides of HGH such as bloating and joint pain & swelling. Most people can tolerate up to approximately 2 IU’s per day with few sides, so that would be a good place to start.

For many using this as a general health supplement, that is as high as you will need to go. For others this will be only the start. Above 2.5 – 3 IU’s, I would definitely suggest that your split your injections into two per day instead of one unless it is just not feasible to do so. In my experiences, I have ran doses as high as 10 IU’s per injection, but at those doses I have suffered greatly with joint pain and bloating to the point of feeling like a Goodyear blimp. Also in my experimentation it seems that at least for me, keeping my individual doses down to 3-3.5 IU’s a piece, I more effectively elevate my IGF-1 levels while minimizing the need for mega-doses of HGH.

Here is what a good ramp up strategy would look like:
Weeks 1-4 = HGH 2 IU’s one injection
Week 5 = HGH 2.5 IU’s one injection
Week 6 = HGH 3.0 IU’s split into two injections of 1.5 IU’s each
Week 7 = HGH 3.5 IU’s split into two injections of 1.75 IU’s each
And so forth until you reach your desired dose.

If at any point in this progression you begin to have unbearable bloating or joint pain, drop the dose by 25% and hold it at this lower dosage for a couple of weeks. If the sides subside, begin your progression back up toward your desired level. If the sides remain, lower your dose again and hold it at the lower level for two weeks before beginning the upward progression. This method will keep your HGH experience a good one and side free for the most part.

For a normal cycle of 5-8 months in length, injecting once or twice a day, 7 days a week should be fine. While there are studies that suggest that the suppression and negative feedback from exogenous HGH is short lived (about 4 hours from time of injection), there are no large-scale studies to indicate safety of everyday injections in long-term use. There are studies by anti-aging groups demonstrating that a day or two off per week is adequate to protect the pituitary and its triggers over long cycles. If your use of HGH becomes more a lifestyle than a single cycle, I would consider running it 5 on/2 off, or 6 on/ 1 off until such time as we have reliable data demonstrating long-term safety sans any degradation of your own output or the triggers initiating that output. I have personally experimented with just about every conceivable injection strategy I could devise. What I can say about the anti-aging doctor’s supposition is that it panned out for me. I have recently come off of a 7-year run of HGH. I personally pull my own blood panels every six weeks routinely. After many months of being off of HGH, I now have the same profile I had before I began its use many years ago … high normal for my age. All levels and markers are perfectly normal.

Another option would be to run your HGH cycle everyday for the first two months to get your IGF-1 levels elevated quickly and to a level to assist you in an anabolic way, then drop back to 5 days a week. If you can tolerate the sides of higher doses, running the same weekly dose divided every other day is fine as well. The list goes on and frankly is an individual proposition. What seems to be of greatest import is that your weekly supplement of HGH is respectable enough to provide the desired benefit.

TIMING

As described above, the body produces HGH is a pulsatile fashion throughout the day with the heaviest pulses occurring approximately 2 hours or so after going to bed and as you fall into a deep sleep. Injectible HGH is completely absorbed and put to use within approximately 3 hours. The strategy with respect to timing depends somewhat on our age and the other elements of our cycle. As you will see below, there is no single best strategy … it depends a lot on your individual situation.

For those that are between their late 20’s and early 50’s, there is still a reasonable chance that your own endogenous production of HGH is at a reasonable level. The best time to take and injection, this being the case, would be early morning …. After your body’s own release of HGH in the night. If you get up to go to the bathroom in the early morning (3 -5am), this is probably the perfect time to take a couple of units of HGH. This will be the least disruptive time to take an injection of HGH. The second best time would be first thing in the morning when you wake up.

If you are splitting your doses, the two times of the day when your cortisol levels are at peak are when you wake up and in the early afternoon. This being the case, another good strategy is to take your HGH injections at these times. Cortisol is very catabolic by nature and a well -timed HGH injection can go a long way toward blunting this effect.

If you are in your late 50’s or beyond, or if for some reason you have a condition that has rendered your pituitary incapable of a normal release of HGH, a great time to take HGH is right before bed. This allows you to closely mimic the natural pattern that would occur if your pituitary were functioning properly. For the rest of us, taking your HGH right before bed is going to end up creating a negative feedback loop, robbing you of your body’s own nightly pulse of HGH. While the jury is still out (conflicting studies) as to the absolute nature of the negative feedback time, it is clear that the closer we push our injection to the time our body is ready to give us its biggest pulses of HGH, we are going to end up derailing our own triggers and secretion.

Yet another strategy should be considered if you are using insulin with your HGH. Insulin should be used immediately post workout. HGH and insulin do some great things together – they shuttle nutrients in a very complimentary way with each other, and the combination of HGH and Insulin create the best environment for IGF-1 production from the liver. If you are using insulin immediately post workout, taking a few IU’s of HGH pre-workout will allow HGH to offer all of its fat mobilizing effects while getting your HGH and Insulin to the liver at about the right time for huge IGF-1 releases.