An electrogenetic interface to program mammalian gene expression by direct current

An electrogenetic interface to program mammalian gene expression by direct current - Printable Version

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An electrogenetic interface to program mammalian gene expression by direct current - 45cmbiceps - 08-05-2023

Found something interesting today:

Quote:Wearable electronic devices are playing a rapidly expanding role in the acquisition of individualsâ health data for personalized medical interventions; however, wearables cannot yet directly program gene-based therapies because of the lack of a direct electrogenetic interface. Here we provide the missing link by developing an electrogenetic interface that we call direct current (DC)-actuated regulation technology (DART), which enables electrode-mediated, time- and voltage-dependent transgene expression in human cells using DC from batteries. DART utilizes a DC supply to generate non-toxic levels of reactive oxygen species that act via a biosensor to reversibly fine-tune synthetic promoters. In a proof-of-concept study in a type 1 diabetic male mouse model, a once-daily transdermal stimulation of subcutaneously implanted microencapsulated engineered human cells by energized acupuncture needles (4.5 V DC for 10 s) stimulated insulin release and restored normoglycemia. We believe this technology will enable wearable electronic devices to directly program metabolic interventions.